The National Lung Matrix Trial is coordinated by the Early Drug Development (EDD) Trial Management Team based within the Cancer Research UK Clinical Trials Unit (CRCTU) at the ºÚÁϳԹÏÍø.
The Chief Investigator and Chief Biostatistician are also based at the ºÚÁϳԹÏÍø and work closely with the team.
Lead Investigators contribute to the National Lung Matrix Trial by deputising some of the Chief Investigator’s responsibilities for a specific Arm of the trial.
The Trial Management Group (TMG) is a group of professionals from many different fields and organisations. The TMG meets several times a year in order to assist with overall management of the trial and to make important trial related decisions.
The Trial Steering Committee (TSC) is a group of independent professionals, whose role is to provide overall supervision for the trial on behalf of the Trial Sponsor (ºÚÁϳԹÏÍø) and the Trial Funder (Cancer Research UK). They ensure that the trial is performed in line with the high standards of Good Clinical Practice (GCP), most importantly focusing on the safety and well-being of the patients involved.
A Principal Investigator at each of the hospitals running the National Lung Matrix Trial takes overall responsibility for ensuring that the trial is conducted correctly.
Chief Investigator
Professor of Medical Oncology
Chief Investigator of the National Lung Matrix Trial
Institute of Immunology and Immunotherapy
- Email
- g.middleton@bham.ac.uk
Chief Biostatistician
Professor of Biostatistics
Director of Statistics, Cancer Research UK Clinical Trials Unit
- Email
- l.j.billingham@bham.ac.uk
Lead Investigators
- Arm A, B, C, E, H & J : Professor Gary Middleton
- Arm D: , Consultant Medical Oncologist, The Royal Marsden NHS Foundation Trust
- Arm F: , Associate Professor, The University of Texas MD Anderson Cancer Centre
- Arm G: , Consultant in Medical Oncology, The Christie NHS Foundation Trust
- Arm NA Cohort NA1: , Guy's and St Thomas' NHS Foundation Trust, Professor of Experimental Cancer Medicine
- Dr Joshua Savage, Early Drug Development Trial Management Team Leader, ºÚÁϳԹÏÍø
- Dr Manita Mehmi, Senior Trial Coordinator, ºÚÁϳԹÏÍø
- Anita Kumari, Trial Coordinator, ºÚÁϳԹÏÍø
- Peter Fletcher, Trial Statistician, ºÚÁϳԹÏÍø
- Karen James, Trial Monitor, ºÚÁϳԹÏÍø
- Stuart Ordish, Programmer, ºÚÁϳԹÏÍø
- Sarah Todd, Data Manager, ºÚÁϳԹÏÍø
- Chair: , Consultant Medical Oncologist, The Royal Marsden NHS Foundation Trust
- , Professor of Medical Oncology, ºÚÁϳԹÏÍø
- , Professor of Biostatistics, ºÚÁϳԹÏÍø
- , Associate Professor, The University of Texas MD Anderson Cancer Centre
- , Consultant in Medical Oncology, The Christie NHS Foundation Trust
- , Guy's and St Thomas' NHS Foundation Trust, Professor of Experimental Cancer Medicine
- , Consultant Histopathologist, Royal Brompton & Harefield NHS Foundation Trust
- , University College London Hospitals NHS Foundation Trust, Chair in Personalised Medicine
- , Consultant Histopathologist, University Hospitals Birmingham NHS Foundation Trust
- , Patient Representative
- , Professor and Consultant in Thoracic Medical Oncology, University Hospitals of Leicester NHS Trust
- , Professor of Medical Oncology, University College London Hospitals NHS Foundation Trust,
- , Professor of Respiratory Medicine, University College London Hospitals NHS Foundation Trust
- , Consultant Cardiothoracic Radiologist, Royal Brompton & Harefield NHS Foundation Trust
- , Honorary Consultant Oncologist, Sanger Institute & Cambridge University Hospitals NHS Foundation Trust
- Mrs Amisha Desai, Advanced Clinical Pharmacist – Trials, University Hospitals Birmingham NHS Foundation Trust
- Dr Joshua Savage, Early Drug Development Trial Management Team Leader, ºÚÁϳԹÏÍø
- Dr Manita Mehmi, Senior Trial Coordinator, ºÚÁϳԹÏÍø
- Peter Fletcher, Trial Statistician, ºÚÁϳԹÏÍø
- Karen James, Trial Monitor, ºÚÁϳԹÏÍø
- Stuart Ordish, Programmer, ºÚÁϳԹÏÍø
- Amanda Farley, Institute of Applied Health Research
- Yvonne Wallis, West Midlands Regional Genetics Laboratory, Birmingham Women's and Children’s NHS Foundation Trust
- Chair: , Honorary Consultant in Medical Oncology, University College London Hospitals NHS Foundation Trust
- Independent member:, Consultant Pathologist, Aberdeen Royal Infirmary
- Independent member: Professor James Wason, Professor of Biostatistics at Newcastle University
- Independent member: Dr Craig Dick, Clinical Senior Lecturer, NHS Greater Glasgow and Clyde
- Principal Investigator: , Lecturer in Medical Oncology, The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Principal Investigator: , Consultant Clinical Oncologist, Cambridge University Hospitals NHS Foundation Trust
- Patient Representative: Mr Mat Baker
- Dr David Gilligan, Cambridge University Hospitals NHS Foundation Trust
- Dr Paul Shaw, Velindre NHS Trust
- Dr Melanie Mackean, NHS Lothian
- Dr Nicola Steele, NHS Greater Glasgow and Clyde
- Dr Pooja Jain, Leeds Teaching Hospitals NHS Trust
- Professor Sanjay Popat, The Royal Marsden NHS Foundation Trust
- Dr Danielle Power, Imperial College Healthcare NHS Trust
- Dr Yvonne Summers, The Christie NHS Foundation Trust
- Dr Alastair Greystoke, The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Dr Sarah Danson, Sheffield Teaching Hospitals NHS Foundation Trust
- Dr Judith Cave, Southampton University Hospitals NHS Trust
- Professor James Spicer, Guy's and St Thomas' NHS Foundation Trust
- Dr John Conibear, Barts Health NHS Trust
- Dr Paula Scullin, Belfast Health and Social Care Trust
- Professor Dean Fennell, University Hospitals of Leicester NHS Trust
- Professor Denis Talbot, Oxford University Hospitals NHS Foundation Trust
- Dr Martin Forster, University College London Hospitals NHS Foundation Trust
- Dr Joyce Thompson, Heart of England NHS Foundation Trust
- Dr Gillian Price, NHS Grampian
- Dr Elizabeth Toy, Royal Devon & Exeter NHS Foundation Trust
- Dr Riyaz Shah, Maidstone and Tunbridge Wells NHS Trust
- Dr Muthukumar Daksinamoorthy, Colchester Hospital University NHS Foundation Trust
- Dr Muthaiah Sivaramalingam, Blackpool Teaching Hospitals NHS Foundation Trust
- Dr Carles Escriu, Clatterbridge Cancer Centre NHS Foundation Trust
- Dr Tom Geldart, The Royal Bournemouth and Christchurch NHS Foundation Trust Hospitals
- Dr Adam Dangoor, Bristol Haematology & Oncology Centre