Professor Carl Clarke

Professor Carl Clarke

Department of Applied Health Sciences
Professor of Clinical Neurology
Honorary Consultant Neurologist

Contact details

Telephone
+44 (0)121 507 4073
Fax
+44 (0)121 507 5442
Email
c.e.clarke@bham.ac.uk
Address
ºÚÁϳԹÏÍø
Edgbaston
Birmingham
B15 2TT
UK

Professor Clarke has performed a wide variety of research work in Parkinson's disease over the last 30 years. This includes work on the MPTP primate model of the condition, examination of several potential diagnostic tests, systematic reviews of clinical trials in Parkinson's disease, and work on the effects of Parkinson's disease on quality of life and health economics. He led large pragmatic clinical trials examining medical, surgical and rehabilitation interventions in the condition (PD MED, PD SURG, PD REHAB, PD COMM, PD GEN). He was also the clinical advisor to the Technical Team preparing the NICE 2006 Parkinson's disease guidelines.

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Qualifications

  • FRCP
  • MD
  • MBChB
  • BSc

Teaching

  • Instigator and co-ordinator of

Research

Professor Clarke has a long history of research in Parkinson's disease and headache disorders. He runs large pragmatic clinical trials examining medical, surgical and rehabilitation interventions in Parkinson's disease:

Other activities

  • Founding Editor of Cochrane Movement Disorders Collaborative Review Group 1996-present.
  • Movement disorders clinics at City Hospital, Birmingham, Sandwell and West Birmingham Hospitals NHS Trust.
  • Director of Research and Development, Sandwell and West Birmingham Hospitals NHS Trust 2010-14. 
  • Inaugural Chairman of Association of British Neurologists' Movement Disorders Section 2012-16.
  • Deputy Chair of NIHR Efficacy and Mechanisms Evaluation Board 2014-18.

Publications

Recent publications

Article

Nicoll, A, Brady, MC, Masterson-Algar, P, Burton, C, Beaton, G, Dickson, S, Caulfield, M, Smith, CH, Clarke, CE, Ives, N, Jowett, S, Rick, C, Woolley, R & Sackley, CM 2025, '', International Journal of Language & Communication Disorders.

Sackley, CM, Rick, C, Brady, MC, Woolley, R, Burton, C, Patel, S, Masterson-Algar, P, Nicoll, A, Smith, CH, Jowett, S, Ives, N, Beaton, G, Dickson, S, Ottridge, R, Sharp, L, Nankervis, H, Clarke, CE & PD COMM Collaborative Group 2024, '', BMJ, vol. 386, e078341.

Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium 2022, '', Movement Disorders, vol. 37, no. 4, pp. 857-864.

PD Med Collaborative Group 2021, '', Movement Disorders, vol. 36, no. 9, pp. 2136-2143.

Scobie , S, Jowett, S, Lambe, T, Patel, S, Woolley, R, Rowland, N, Rick, C, Smith, C, Brady , M, Clarke, CE & Sackley, C 2021, '', Pilot and Feasibility Studies, vol. 7, no. 1, 154.

Gray, R, Patel, S, Rowland, N, Rick, C, Woolley, R, Muzerengi, S, Gray, A, Jenkinson, C, McIntosh, E, Wheatley, K, Williams, A, Clarke, CE & PD Med Collaborative Group 2021, '', JAMA Neurology.

Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage-PD) consortium 2021, '', Journal of Parkinson's Disease, pp. 267-282.

Sackley, C, Rick, C, Au, P, Brady , MC, Beaton , G, Burton, C, Caulfield, M, Dickson , S, Dowling, F, Hughes, M, Rowland, N, Jowett, S, Masterson-Algar, P, Nicoll , A, Patel, S, Smith , CH, Woolley, R & Clarke, CE 2020, '', Trials, vol. 21, no. 1, 436.

Lang, AE, de Bie, RMA, Clarke, CE, Espay, AJ & Fox, SH 2020, '', The Lancet Neurology, vol. 19, no. 8, pp. 643-644.

Herd, C, Tomlinson, C, Rick, C, Scotton, W, Edwards, J, Ives, N, Clarke, CE & Sinclair, A 2019, '', BMJ open, vol. 9, no. 7, e027953.

Smith, CH, Patel, S, Woolley, RL, Brady, MC, Rick, CE, Halfpenny, R, Rontiris, A, Knox-Smith, L, Dowling, F, Clarke, CE, Au, P, Ives, N, Wheatley, K & Sackley, CM 2019, '', Clinical Linguistics & Phonetics, vol. 33, no. 10-11, pp. 1063-1070.

American Genome Center 2019, '', Movement Disorders, vol. 34, no. 12, pp. 1851-1863.

Herd, C, Cl, T, Rick, C, Scotton, WJ, Edwards, J, Ives, N, Clarke, CE & Sinclair, A 2018, '', Cochrane Database of Systematic Reviews, no. 6, CD011616.

Review article

Carroll, C, Clarke, CE, Grosset, D, Rather, A, Mohamed, B, Parry, M, Reddy, P, Fackrell, R & Chaudhuri, KR 2024, '', Journal of Parkinson's Disease, vol. 14, no. 1, pp. 53-63.

de Bie, RMA, Clarke, CE, Espay, AJ, Fox, SH & Lang, AE 2020, '', The Lancet Neurology, vol. 19, no. 5, pp. 452-461.

Expertise

Parkinson's Disease