Dr Carolina Rezaval BSc, MSc, PhD

Dr Carolina Rezaval

School of Biosciences
Associate Professor

Contact details

Email
c.rezaval@bham.ac.uk
Twitter
Address
603, School of Biosciences
ºÚÁϳԹÏÍø
Edgbaston
Birmingham
B15 2TT
UK

Our lab uses the fruit fly Drosophila to unravel the mechanisms underlying behavioural choices. By studying how the brain makes decisions at a genetic, cellular and circuit level, in an accessible experimental system, we aim to reveal fundamental principles that might be present across species.

Qualifications

  • 2009 PhD in Biology. University of Buenos Aires, Argentina.
  • 2004 BSc, MSc in Biology. University of Buenos Aires, Argentina.

Biography

Carolina Rezaval was born in Patagonia, Argentina. She received a Master's and PhD in Biology from the University of Buenos Aires. Her PhD research, supervised by ,  focused on identifying genes involved in neurodegeneration that lead to abnormal circadian behaviour in Drosophila.

She subsequently conducted her post-doctoral research at the University of Oxford, where she studied the genetic and neural basis of innate sexual behaviours in Drosophila. As a BBSRC researcher co-investigator in Professor  at the University of Oxford, she focused on understanding how the brain differs between the sexes and how these differences explain distinct behaviours exhibited by male and female flies. She discovered a specific subset of neurons which, when activated, induces female fruit flies to exhibit male-like behaviours, demonstrating that the neural circuitry for male courtship behaviours indeed exists in the female fly brain but remains dormant.

In April 2018, Carolina was awarded a Birmingham Fellowship to start her  at the ºÚÁϳԹÏÍø. Her lab focuses on understanding how the brain makes decisions when faced with conflicting options, using Drosophila as a model organism. In 2021, Carolina was promoted to Associate Professor and later became the module leader for Third-Year Cellular Neurobiology at the School of Biosciences. For more information, visit her lab website: .

Teaching

BIO379: Cellular Neurobiology (Module leader)

23318/23319: Cell Biology and Physiology/Essentials of Cell Biology and Physiology (lecturer)

34136: Personal and Academic Development (tutor)

Postgraduate supervision

PhD projects are offered in the general area of Behavioural Neurobiology using the fruit-fly Drosophila as a model organism. We study how the brain responds when there are conflicting options available, and how it chooses amongst them. By studying how the brain makes decisions at a genetic, cellular and circuit level, in an accessible experimental system, we aim to reveal fundamental principles underlying behavioural choices that might be present across species. 

Technical approaches include genetics, molecular biology, optogenetics/thermogenetics, behavioural assays, immunohistochemistry, confocal microscopy and functional imaging (in collaboration with other research groups). 

Masters projects are offered in the field of Behavioural Neurobiology as above. 

Interested in joining the lab for MSc, MSci, and MRes projects or PhD training? Please, contact Dr Carolina Rezaval by email c.rezaval@bham.ac.uk

We are keen to host domestic and international students who have secured their own funding.

The ºÚÁϳԹÏÍø offers a number of competitive BBSRC funded PhD positions each year as part of the MIBTP doctoral training scheme, in association with the Universities of Warwick and Leicester. Application deadlines are every January.  If you are interested in this scheme, please get in touch by email to discuss potential projects and applications.

Research

Birmingham Fly Facility

Animals engage in daily activities that are essential for survival and reproduction, such as feeding, mating or fighting for resources.

How does an animal prioritise one behaviour over others? We know that cues conveying external information (e.g., threats from other animals, access to food) and internal state (e.g., fear, hunger) guide behavioural choices. However, how the brain selects specific actions remains unknown.
 
Our lab addresses this fascinating question using the fruit fly model, Drosophila. Fruit flies exhibit complex behaviours that are controlled by a relatively small brain. Thanks to sophisticated tools available in the fruit fly, we can interrupt specific genes, as well as visualise and manipulate individual neurons with great resolution. With these tools, we can study how the fly brain responds when there are conflicting options available, and how it chooses amongst them​.

By studying how the brain makes decisions at a genetic, cellular and circuit level in an accessible experimental system, we aim to reveal fundamental principles underlying behavioural choices that might be present across species.

Other activities

Science outreach

  • Science Evening, SS Philip and James’ Church of England 2017
  • National History Museum in Oxford () 2017
  • 2016

Publications

Recent publications

Article

Cazalé-Debat, L, Scheunemann, L, Day, M, Fernandez-d.V. Alquicira, T, Dimtsi, A, Zhang, Y, Blackburn, LA, Ballardini, C, Greenin-Whitehead, K, Reynolds, E, Lin, AC, Owald, D & Rezaval, C 2024, '', Nature, vol. 634, no. 8034, pp. 635-643.

von Philipsborn, AC, Shohat-Ophir, G & Rezaval, C 2023, '', Cold Spring Harbor Protocols, vol. 2023, no. 7, pp. 459-465.

von Philipsborn, AC, Shohat-Ophir, G & Rezaval, C 2023, '', Cold Spring Harbor Protocols, vol. 2023, no. 7, pp. 472-480.

von Philipsborn, AC, Shohat-Ophir, G & Rezaval, C 2023, '', Cold Spring Harbor Protocols, vol. 2023, no. 7, pp. 431-439.

von Philipsborn, AC, Shohat-Ophir, G & Rezaval, C 2023, '', Cold Spring Harbor Protocols, vol. 2023, no. 7, pp. 466-471.

von Philipsborn, AC, Shohat-Ophir, G & Rezaval, C 2023, '', Cold Spring Harbor Protocols, vol. 2023, no. 7, pp. 450-458.

Fernandez-Acosta, M, Romero, JI, Bernabó, G, Velázquez-Campos, GM, Gonzalez, N, Mares, ML, Werbajh, S, Avendaño-Vázquez, LA, Rechberger, GN, Kühnlein, RP, Marino-Buslje, C, Cantera, R, Rezaval, C & Ceriani, MF 2022, '', BMC Biology, vol. 20, no. 1, 233.

Rose, S, Beckwith, EJ, Burmester, C, May, RC, Dionne, MS & Rezaval, C 2022, '', Proceedings of the Royal Society B: Biological Sciences, vol. 289, no. 1974, 20220492.

Cheriyamkunnel, SJ, Rose, S, Jacob, PF, Blackburn, LA, Glasgow, S, Moorse, J, Winstanley, M, Moynihan, PJ, Waddell, S & Rezaval, C 2021, '', Current Biology, vol. 31, no. 19, pp. 4231-4245.e4.

Rezaval, C, Pattnaik, S, Pavlou, HJ, Nojima, T, Brüggemeier, B, D’Souza, LAD, Dweck, HKM & Goodwin, SF 2016, '', Current Biology, vol. 26, no. 18, pp. 2508-2515.

Nojima, T, Neville , MC, Lin, A & Goodwin, SF 2014, '', Current Biology, vol. 24, no. 7, pp. 725-730.

Beckwith, EJ, Gorostiza, AE, Berni, J, Rezaval, Pérez-Santángelo, A, Nadra, AD & Ceriani, MF 2013, '', PLoS Biology.

Chapter

Rezaval, C 2015, . in Young perspectives for old diseases. Bentham Science Publishers.

Editorial

O'Leary, T, Hauser, TU, Ryan, TJ & Rezaval, C 2022, '', European Journal of Neuroscience.

Preprint

Rose, S, Beckwith, EJ, Burmester, C, May, RC, Dionne, MS & Rezaval, C 2021 '' bioRxiv.