Professor Aga Gambus

Professor Aga Gambus

Department of Cancer and Genomic Sciences
Professor of DNA Metabolism
Wellcome Trust and Lister Fellow

Contact details

Telephone
+44 (0)121 414 58688
Email
a.gambus@bham.ac.uk
Twitter
Address
Department of Cancer and Genomic Sciences
黑料吃瓜网
Edgbaston
Birmingham
B15 2TT
UK

Professor Aga Gambus moved to Cancer Sciences in 2011 to start her independent research. She was awarded MRC Career Development Award and Birmingham Fellowship supporting her research into regulation of DNA replication through small protein modifiers: ubiquitin and SUMO.

Aga’s group discovered the first elements of the mechanism of replication machinery disassembly at termination of DNA replication. Due to this exciting novel discoveries Aga was awarded the Lister Institute Research Award in 2015 and Wellcome Trust Investigator Award in 2019 to continue her research on replisome unloading.

Qualifications

  • PhD in Cancer Research, University of Manchester, 2006
  • MSc in Biotechnology, Jagiellonian University, Krakow, Poland, 2002

Teaching

  • Tutor on “Genetic basis of cancer” within MBChB module ‘Cancer: Causes to Cures’.
  • BMedSc Year 3 course “DNA damage pathways in human disease”
  • BSc Biomedical Science Year 1 course: “Cellular Biochemistry and Biology”
  • Masterclass for MIBTP PhD students
  • Supervising PhD, masters, ERASMUS, summer and undergraduate students

Postgraduate supervision

Dr Gambus is interested in supervising doctoral research in the following areas:

Regulation of eukaryotic DNA replication
DNA replication and tumor development
Novel anticancer therapy targets essential for DNA replic

Other activities

  • Reviewer for grant funding bodies and journals.
  • Member of Panel V Research Area: Signalling in Biochemical Society
  • Member of The Biochemical Society, British Association for Cancer Research (BACR),  European Association for Cancer Research (EACR), British Society for Cell Biology (BSCB), EMBO Expert Women in Life Sciences (WiLS)
  • External PhD examiner

Publications

Recent publications

Article

Poovathumkadavil, D, Reynolds-Winczura, A, Skagia, A, Passaretti, P, Sadurni, MM, Kingsley, G, Leitner, A, Saponaro, M & Gambus, A 2025, '', Nucleic Acids Research, vol. 53, no. 13, gkaf530.

Holmes, EP, Gamill, MC, Provan, JI, Wiggins, L, Ruskov谩, R, Whittle, S, Catley, TE, Main, KHS, Shephard, N, Bryant, HE, Gilhooly, NS, Gambus, A, Ra膷ko, D, Colloms, SD & Pyne, ALB 2025, '', Nature Communications, vol. 16, no. 1, 5482.

Jones, RM, Ruiz, JH, Scaramuzza, S, Nath, S, Liu, C, Henklewska, M, Natsume, T, Bristow, RG, Romero, F, Kanemaki, MT & Gambus, A 2024, '', iScience, vol. 27, no. 7, 110260.

Passaretti, P, Cvetkovic, MA, Costa, A & Gambus, A 2024, '', STAR Protocols, vol. 5, no. 3, 103237.

Kingsley, G, Skagia, A, Passaretti, P, Fernandez-Cuesta, C, Reynolds-Winczura, A, Koscielniak, K & Gambus, A 2023, '', Nucleic Acids Research.

Cvetkovi膰, M, Passaretti, P, Butryn, A, Reynolds-Winczura, A, Kingsley, G, Skagia, A, Fernandez Cuesta, C, Poovathumkadavil, D, George, R, Chauhan, A, Jhujh, S, Stewart, G, Gambus, A & Costa, A 2023, '', Molecular Cell, vol. 83, no. 22, pp. 4017-4031.e9.

Scaramuzza, S, Jones, RM, Sadurni, MM, Reynolds-Winczura, A, Poovathumkadavil, D, Farrell, A, Natsume, T, Rojas, P, Cuesta, CF, Kanemaki, MT, Saponaro, M & Gambus, A 2023, '', Nature Communications, vol. 14, no. 1, 5071.

Tarcan, Z, Poovathumkadavil, D, Skagia, A & Gambus, A 2022, '', The Journal of biological chemistry, vol. 298, no. 8, 102234.

Blakemore, D, Vilaplana-Lopera, N, Almaghrabi, R, Gonzalez, E, Moya, M, Ward, C, Murphy, G, Gambus, A, Petermann, E, Stewart, GS & Garc铆a, P 2021, '', EMBO Reports, vol. 22, no. 5, e51120.

Hadzhiev, Y, Qureshi, HK, Wheatley, L, Cooper, L, Jasiulewicz, A, Van Nguyen, H, Wragg, JW, Poovathumkadavil, D, Conic, S, Bajan, S, Sik, A, Hutv脿gner, G, Tora, L, Gambus, A, Fossey, JS & M眉ller, F 2019, '', Nature Communications, vol. 10, no. 1, 691, pp. 691.

Moreno, SP, Jones, RM, Poovathumkadavil, D, Scaramuzza, S & Gambus, A 2019, '', Life Science Alliance, vol. 2, no. 2, e201900390.

Preprint

Scaramuzza, S, Muste Sadurni, M, Poovathumkadavil, D, Natsume, T, Rojas, P, Kanemaki, MT, Saponaro, M & Gambus, A 2022 '' bioRxiv.

Review article

Jones, RM, Reynolds-Winczura, A & Gambus, A 2024, '', Biology, vol. 13, no. 4, 233.

Moreno, SP & Gambus, A 2020, '', Biochemical Society Transactions, vol. 48, no. 3, pp. 823-836.

Working paper

Gambus, A, Moreno, SP, Jones, RM & Poovathumkadavil, D 2018 '' bioRxiv, pp. 1-27.