Dr Sovan Sarkar BSc, MSc, PhD

Dr Sovan Sarkar

Department of Cancer and Genomic Sciences
Associate Professor

Contact details

Telephone
+44 (0)121 414 6669
Fax
+44 (0)121 414 5475
Email
s.sarkar@bham.ac.uk
Address
Department of Cancer and Genomic Sciences
ºÚÁϳԹÏÍø
Edgbaston
Birmingham
B15 2TT
UK

Dr Sovan Sarkar is an Associate Professor at the ºÚÁϳԹÏÍø, and holds the distinction of Former Fellow for life at Hughes Hall, University of Cambridge. He is also involved in setting up academic and research collaborations with India. His laboratory studies the biological process of autophagy, which is an intracellular degradation pathway essential for cellular survival. Using human embryonic stem cells (hESCs) and disease-specific human induced pluripotent stem cells (hiPSCs), he works on the regulation and therapeutic application of autophagy in relation to human physiology and diseases. He aims to develop a pipeline originating from basic biology to drug discovery, and potentially translate the findings for biomedical applications. 

His research has been funded by grants from the Wellcome Trust, LifeArc and UKIERI (UK-India Education and Research Initiative), amongst others. He has also hosted researchers with Newton Bhabha PhD Placement Award, Rutherford Fellowship, ºÚÁϳԹÏÍø India Institute Visiting Fellowship and ºÚÁϳԹÏÍø Brazil Visiting Fellowship, amongst others.

Sovan has made several contributions during his tenure at University of Cambridge towards the identification of mTOR-independent signalling pathways and small molecules modulating autophagy. These findings not only provided mechanistic insights into the cell biology of this process, but also generated potential therapeutic candidates for diverse human diseases, including a number of neurodegenerative diseases, where upregulating autophagy acts as a protective pathway.

His work at Whitehead Institute in Massachusetts Institute of Technology involves the fundamental aspects of autophagy in hESCs, and its deregulation in hiPSC-based disease models of neurodegenerative and lysosomal storage disorders. He has authored more than 50 scientific publications, which have collectively received ~ 12000 citations, and have generated a number of patents and research features. His notable awards include Gates Cambridge Scholarship, Hughes Hall Research Fellowship, Biochemical Society Early Career Research Award in Cell Biology and Birmingham Fellowship.

See Sovan Sarkar for further details.

Qualifications

  • PhD in Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, UK, 2007.
  • MSc in Biotechnology, School of Biotechnology, Madurai Kamaraj University, India, 2002.
  • BSc in Physiology (Hons), Presidency College, University of Calcutta, India, 2000.

Biography

Dr Sovan Sarkar qualified with a BSc (Hons) in Physiology from Presidency College in 2000, securing first rank at University of Calcutta, India. He went on to study for an MSc in Biotechnology from Madurai Kamaraj University, India, completing in 2002. During his studies in India, he received several academic and research awards, including Summer Research Fellowship from Jawaharlal Nehru Centre for Advanced Scientific Research, Department of Biotechnology Studentship from Government of India and the distinction of Rajiv Gandhi Science Talent Research Fellow. 

Sovan received the Gates Cambridge Scholarship in 2002 for pursuing his PhD at Cambridge Institute for Medical Research in University of Cambridge, UK, in the laboratory of Professor David Rubinsztein. He graduated in 2007 and continued his research at Cambridge as a Post-Doctoral Research Associate until 2009. During this time, he was elected as a Junior Research Fellow at Hughes Hall, a college in the University of Cambridge, and later received the distinction of Former Fellow for life. In 2010, Sovan joined the laboratory of Professor Rudolf Jaenisch at the Whitehead Institute for Biomedical Research in Massachusetts Institute of Technology, USA as a Post-Doctoral Associate. 

Sovan has been working in the field of autophagy for over a decade since his graduate studies in Cambridge. He made numerous contributions to this field, especially towards understanding the cellular signalling pathways and identification of chemical modulators regulating this intracellular process. One of his major contributions is uncovering the existence of mTOR-independent regulation of autophagy that has been instrumental in the discovery of a large number of candidate drugs of biomedical relevance. These small molecule autophagy enhancers are considered to be potential therapeutic candidates not only for the treatment neurodegenerative diseases but also for diverse human diseases where autophagy acts as a protective pathway.

Furthermore, he has provided mechanistic insights on the impairment of autophagy in certain neurodegenerative and lysosomal storages disorders, and how this can be rescued by chemical perturbations. In recent years, he has been working on the regulation and therapeutic application of autophagy in human disease-relevant cell types using human embryonic stem cells and disease-specific induced pluripotent stem cells. 

Sovan has co-authored more than 60 scientific publications that have collectively received over 19,000 citations. His work has generated a number of patents, attracted press releases, and has been highlighted in Nature Reviews Drug Discovery, UK Channel 4 news, The Times of India, Cambridge University, Gates Cambridge and Whitehead Institute, amongst others. Based on his scientific accomplishments, he has received several travel and academic awards, including the Biochemical Society Early Career Research Award in Cell Biology, and has been featured as an autophagy researcher in the April 2014 issue of the journal, Autophagy.

Postgraduate supervision

Dr Sarkar is interested in supervising Doctoral and Masters research students in the following areas: 

  • The role and regulation of autophagy in human embryonic stem cells and in differentiated adult cell types.
  • The molecular mechanisms of mammalian autophagy in its role in cellular homeostasis, neurodegeneration, aging and metabolism.
  • Mechanisms of cellular degeneration and proteostasis in disease-relevant human cell types derived from disease-specific induced pluripotent stem cells.
  • Drug discovery in human disease-affected cell types derived from disease-specific induced pluripotent stem cells. 

If you are interested in studying any of these subject areas please contact Dr Sarkar directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk

Research

Research Themes

Cell biology of autophagy, Intracellular trafficking pathways, Proteostasis, Human embryonic stem cells, Induced pluripotent stem cell based disease models, Neurodegeneration, Ageing, Lysosomal storage diseases, Chemical screening for drug discovery.

For details of research, please see Sovan Sarkar’s .

Video - Biochemical Society Early Career Research Award Lecture by Dr Sovan Sarkar (2012):

Funding

  • Birmingham Fellowship
  • Wellcome Trust
  • UKIERI DST
  • LifeArc

Other activities

Society Memberships

  • UK Autophagy Network, UK
  • Autophagy India Network, India
  • International Society for Stem Cell Research, USA
  • Biochemical Society, UK
  • Gates Scholars’ Society, Cambridge, UK
  • Hughes Hall Society, Cambridge, UK
  • Presidency College Alumni Association, Kolkata, India

ºÚÁϳԹÏÍø Associations

  • ºÚÁϳԹÏÍø India Institute
  • ºÚÁϳԹÏÍø Brazil Forum
  • Institute of Cancer and Genomic Sciences
  • Centre for Rare Disease Studies (CRDS) Birmingham
  • Birmingham University Stem Cell Centre

Awards

  • British Council Newton Trust Award (2015).
  • Birmingham Fellowship, ºÚÁϳԹÏÍø (2014–Present).
  • Whitehead Institute Postdoc Association Education Award (2013). 
  • Biochemical Society Early Career Research Award in Cell Biology (2012). 
  • Hughes Hall Former Fellow Distinction, University of Cambridge (2010–Present). 
  • Hughes Hall Junior Research Fellowship, University of Cambridge (2007–2010). 
  • Academy of Achievement Student Delegate Award (2004).
  • Honorary Elizabeth Cherry Research Students’ Scholarship (2004).
  • Gates Cambridge Scholarship (2002–2005). 
  • Department of Biotechnology Studentship, Government of India (2000–2002).
  • Rajiv Gandhi Science Talent Research Fellow Distinction (2000).

Patents

  • Regulating autophagy. Bradner J.E., Shen J.P., Perlstein E.O., Rubinsztein D.C., Sarkar S.and Schreiber S.L. World Intellectual Property Organization  (09 Oct 2008). 
  • cAMP-dependent induction of autophagy. Rubinsztein D.C., Sarkar S.and Williams A. World Intellectual Property Organization  (21 Aug 2008). 
  • Modulation of autophagy by calpain inhibition. Rubinsztein D.C., Sarkar S.and Williams A., Ttofi E., O’Kane C. and Floto R.A. World Intellectual Property Organization  (11 Jan 2007). 
  • Methods of autophagy induction in mammalian cells. Rubinsztein D.C. and Sarkar S. World Intellectual Property Organization  (03 Aug 2006).

Features

Publications

Selected Publications

See for full list of all publications, citations and h-index. See Sovan Sarkar for full details of all publications.

. (2021) Sharma V., Makhdoomi M., Singh L., Kumar P., Khan N., Singh S., Verma H.N., Luthra K., Sarkar S. and Kumar D. Autophagy 17(2): 476-495.

(2020) Sedlackova L., Otten E.G., Scialo F., Shapira D., Kataura T., Carroll B., Seranova E., Rabanal-Ruiz Y., Kelly G., Stefanatos R., Nelson G., Acharjee A., Kenneth N., Trushin S., Zhang T., Bascom C.C., Tasseff R., Isfort R.J., Oblong J.E., Trushina E., Imoto M., Saiki S., Lazarou M., Chronakis M.P., Maddocks O.D.K., Sarkar S.†, Sanz A.† and Korolchuk V.I.†
BioRxiv [pre-print server for biology] doi: https://doi.org/10.1101/2020.01.31.928424. †Joint corresponding authors 

. (2020) Seranova E., Palhegyi A.M., Verma S., Dimova S., Lasry R., Naama M., Sun C., Barrett T., Rosenstock T.R., Kumar D., Cohen M.A., Buganim Y. and Sarkar S. Journal of Molecular Biology 432(8): 2754-2798. 

. (2020) Zatyka M., Sarkar S. and Barrett T. Journal of Molecular Biology 432(8): 2735-2753. 

. (2019) Panda P.K., Fahrner A., Vats S., Seranova E., Sharma V., Chipara M., Desai P., Torresi J., Rosenstock T., Kumar D. and Sarkar S. Frontiers in Cell and Developmental Biology 7: 38. 

. (2019) Seranova E., Ward C., Chipara M., Rosenstock T.R. and Sarkar S. Methods in Molecular Biology 1880: 389-428 

. (2018) Sharma V., Verma S., Seranova E., Sarkar S. and Kumar D. Frontiers in Cell and Developmental Biology 6: 147.

Mishra P., Dauphinee A.N., Ward C., Sarkar S., Gunawardena A.H.L.A.N. and Manjithaya R. (2017) . Autophagy 13(9): 1556-1572.

Carroll, B., Maetzel, D., Maddocks, O.D.K., Otten, G., Ratcliff, M., Smith, G.R., Dunlop, E.A., Passos, J.F., Davies, O.R., Jaenisch, R., Tee, A.R., Sarkar, S. and Korolchuk, V.I. (2016) . eLife 5: e11058.

Brown, A., Patel, S., Ward, C., Lorenz, A., Ortiz, M., DuRoss, A., Wieghardt, F., Esch, A., Otten, E.G., Heiser, L.M., Korolchuk, V.I., Sun, C., Sarkar, S. and Sahay, G. (2016) . Scientific Reports 6: 31750.

Kuo, S.Y., Castoreno, A.B., Aldrich, L.N., Lassen, K.G., Goel, G., Dančík, V., Kuballa, P., Latorre, I., Conway, K.L., Sarkar, S., Maetzel, D., Jaenisch, R., Clemons, P.A., Schreiber, S.L.,Shamji, A.F. and Xavier, R.J. (2015) Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics. 112(31): E4281-E4287.

Maetzel, M.*, Sarkar, S.*, Wang, H.*, Abi-Mosleh, L., Xu, P., Cheng, A.W., Gao, Q., Mitalipova, M. and Jaenisch, R. (2014) . Stem Cell Reports 2(6): 866-880. *Equal contribution 

Buganim Y., Markoulaki S., van Wietmarschen N., Hoke H., Wu T., Ganz K., Akhtar-Zaidi B., He Y., Abraham B.J., Porubsky D., Kulenkampff E., Faddah D.A., Shi L., Gao Q., Sarkar S., Cohen M.A., Goldman J., Nery J.R., Schultz M.D., Ecker J.R., Xiao A., Young R.A., Lansdorp P.M. and Jaenisch R. (2014). Cell Stem Cell 15(3): 295-309. 

Sarkar, S., Carroll, B., Buganim, Y., Maetzel, D., Ng, A.H.M., Cassady, J.P., Cohen, M.A., Chakraborty, S., Wang, H., Spooner, E., Ploegh, H., Gsponer, J., Korolchuk, V.I. and Jaenisch, R. (2013) . Cell Reports 5(5): 1302-1315. 

Sarkar, S. (2013) . Biochemical Society Transactions 41(5): 1103-1130. 

Sarkar, S. (2013) . Drug Discovery Today: Technologies 10(1): e137-e144. 

Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., Buganim, Y., Schroeder, A., Langer, R. and Anderson, D.G. (2013) . Nature Biotechnology 31(7): 653-658. 

Buganim, Y., Itskovich, E., Hu, Y.C., Cheng, A.W., Ganz, K., Sarkar, S., Fu, D., Welstead, G.G.,Page, D.C. and Jaenisch, R. (2012) . Cell Stem Cell 11(3): 373-386. 

Sarkar, S., Korolchuk, V.I., Renna, M., Imarisio, S., Fleming, A., Williams, A., Garcia-Arencibia, M., Rose, C., Luo, S., Underwood, B.R., Kroemer, G., O'Kane, C.J. and Rubinsztein, D.C. (2011) . Molecular Cell 43(1): 19-32. 

Korolchuk, V.I., Saiki, S., Lichtenberg, M., Siddiqi, F.H., Roberts, E.A., Imarisio, S., Jahreiss, L., Sarkar, S., Futter, M., Menzies, F.M., O'Kane, C.J., Deretic, V. and Rubinsztein, D.C. (2011) . Nature Cell Biology 13(4): 453-460. 

Aguado, C.*, Sarkar, S.*, Korolchuk, V.I., Criado, O., Vernia, S., Boya, P., Sanz, P., de Cordoba, S.R., Knecht, E. and Rubinsztein, D.C. (2010) . Human Molecular Genetics 19(14): 2867-2876. *Equal contribution 

Davies, J.E., Rose, C., Sarkar, S. and Rubinsztein, D.C. (2010) . Science Translational Medicine 2(34): 34ra40. 

Sarkar, S., Ravikumar, B., Floto, R.A. and Rubinsztein, D.C. (2009) . Cell Death and Differentiation 16(1): 46-56. 

Williams, A.*, Sarkar, S.*, Cuddon, P.*, Ttofi, E.K., Saiki, S., Siddiqi, F.H., Jahreiss, L., Fleming, A., Pask, D., Goldsmith, P., O’Kane, C.J., Floto, R.A. and Rubinsztein, D.C. (2008) . Nature Chemical Biology 4(5): 295-305. *Equal contribution 

Sarkar, S., Krishna, G., Imarisio, S., Saiki, S., O'Kane, C.J. and Rubinsztein, D.C. (2008) . Human Molecular Genetics 17(2): 170-178. 

Sarkar, S.*, Perlstein, E.O.*, Imarisio, S., Pineau, S., Cordenier, A., Maglathlin, R.L., Webster, J.A., Lewis, T.A., O’Kane, C.J., Schreiber, S.L. and Rubinsztein, D.C. (2007). Nature Chemical Biology 3(6): 331-338. *Equal contribution 

Sarkar, S., Davies, J.E., Huang, Z., Tunnacliffe, A. and Rubinsztein, D.C. (2007) . Journal of Biological Chemistry 282(8): 5641-5652. 

Chakrabortee, S., Boschetti, C., Walton, L.J., Sarkar, S., Rubinsztein, D.C. and Tunnacliffe, A. (2007) . Proceedings of the National Academy of Sciences (PNAS), USA 104(46): 18073-18078. 

Sarkar, S., Floto, R.A., Berger, Z., Imarisio, S., Cordenier, A., Pasco, M., Cook, L.J. and Rubinsztein, D.C. (2005) . Journal of Cell Biology 170(7): 1101-1111.